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Conventional vs. Highly Crosslinked Polyethylene Particles - An In Vivo Comparison of Biologic Activities

Funding:

Orthopedic Research and Education Foundation

Principal Investigator:

Richard Illgen, MD

Lab Website:

(Lab website not available at this time)

Project Summary:

Osteolysis represents the most common long-term cause of failure after total hip arthroplasty. Recent efforts to reduce the incidence of osteolysis include the introduction of highly crosslinked polyethylenes (HXPE). While much is known regarding the biomaterial properties of these promising new polyethylenes, there is little data regarding the relative biologic activities of conventional and HXPE particles. The goal of this study is to employ a murine model to compare the in vivo biologic activities of these particles to test the hypothesis that the wear reduction noted with HXPE will have the intended biologic effect of reducing the incidence of osteolysis.

 

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First published: 07/15/02 Last updated: 11/24/09 webmaster@ortho.wisc.edu
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